The Inflammatory Bowel and Immunobiology Research Institute (IBIRI) at Cedars-Sinai Medical Center is a multidisciplinary basic, translational and clinical research program devoted to mucosal inflammation. Under the direction of Stephan R. Targan, MD, IBIRI is the overarching administrative structure of three distinct yet highly interactive sub-units: IBD Clinical Care and Trials, Translational Research and Basic Science Laboratory Research.


POSITION SUMMARY:
Experienced Biomarker Discovery/Drug Development Scientist to supervise "precision medicine" team in an independent unit focused on inflammation-based diseases. Provide informed decision making in the discovery of biomarkers and development of therapeutic targets, including project planning, experimental protocols and procedures, and oversight of day-to-day unit operations. Work closely with institute director in collaborations with industry representatives. Engage in human in vitro and animal model-based in vivo research to use disease associated genetic variation to explore novel targets and define consequences of variants on initiation and perpetuation of inflammation.


POSITION RESPONSIBILITIES:
Assist the Director as needed to maintain relationships with partners in academia and industry to deliver a robust biomarker/target discovery platform. Use target biology expertise and chemistry knowledge for strategy and method development and validation of new assays, as well as technology transfer to internal and external partners.

Develops, adapts and performs new and established experimental protocols and techniques. Plans and implements research projects in biomarker analysis and therapeutic development using human and murine model based research. Work with computational and bioinformatics scientists to organize data collection, integration and analysis. Use knowledge of target-focused, pathway-focused, and phenotypic assays, as well as secondary assays to confirm and determine the mechanism of action.

Under the direction of the Institute Director, directs research team including post doctoral researchers, research associates and other lab personnel. Supervise and train post doctoral researchers, research associates and laboratory assistants. Develop work plan, devise experiments, identify techniques and approaches, oversee progress, evaluate results. Ensure that optimal timelines are set and met.

Ensure appropriate training of research unit personnel or investigators in sample handling and processing in relation to biomarker assays. Maintain strict adherence to research compliance regulatory standards for human and animal subjects use.

Work with computational and bioinformatics scientists to organize data collection, integration and analysis.

Develop new models, oversee maintenance of mouse colony, experience in in vivo mouse experimentation.

Manage day-to-day lab operations. Act as lab manager, including financial management, budgetary compliance, and human resources responsibilities.
Expand the horizons of medical knowledge.

Cedars-Sinai is one of the most dynamic and highly renowned medical centers in the world and is the largest academic medical center in the western United States. The Burns and Allen Research Institute has one of the largest state-of-the-art clinical and translational research facilities of any private hospital in the nation. As a major community medical center and tertiary referral center, Cedars-Sinai offers an environment of unparalleled opportunity for translational studies.

If you are committed to working at the leading edge of medical discovery, we invite you to join our world-class research organization.

Ensures compliance with state and federal laws, accreditation, professional and regulatory agency standards including quality assurance and licensure requirements within the divisions. Assist in establishing and maintaining a quality assurance program acceptable to CSMC as required by The Joint Commission, state and other agencies, which shall include a systematic review of the quality, safety, and appropriateness of services rendered.

Pursuant to the Minimum Necessary Information Access Policy (#ADM00127), the minimum access to individually identifiable patient information permitted for this individual is secured and maintained in the home department's employee file.

MINIMUM REQUIREMENTS:
PhD or MD/PhD in immunology, molecular biology or related field with at least 4 years of post-doctoral experience, and four years as a research scientist, industry experience is desirable.

Extensive cell biology, biochemistry and molecular biology experience. Strong theoretical understanding of biomarkers and therapeutic target discovery. Strong theoretical and practical knowledge in immunology.

Ability to perform assay and process optimization and validation.

Good written and oral communication skills


ORGANIZATIONAL EXPECTATIONS:
Demonstrates behavior which supports the Medical Center's mission. Attends required orientation and training seminars. Meets productivity and quality standards. Exhibits respect and positive interpersonal skills with patients, clients, the public, managers, staff, and co-workers - a team player. Observes the Medical Center's faculty behavioral expectations and the Medical Staff's code of conduct. Maintains confidentiality of patient care and business matters. Observes Medical Center policies & procedures such as dress code, etc. Protects the safety of others and of the physical plant and equipment. Follows Medical Center policies & procedures.

Demonstrates knowledge of the National Patient Safety Goals. Applies each National Patient Safety Goal as it relates to his/her own job responsibilities. Demonstrates knowledge of the Medical Center's Patient Safety program and plan. Can describe the Medical Center's Significant Adverse Event process. Demonstrates understanding and utilizes the chain of command as it relates to his/her own job. Demonstrates understanding of the Medical Center's Culture of Safety.

To apply, visit us online at:
www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=7873&CurrentPage=1" target="_blank">https:// www.cedars-sinaimedicalcenter.apply2jobs.com/ProfExt/index.cfm?fuseaction=mExternal.showJob&RID=7873&CurrentPage=1

Please reference job # 7835 -Drug Development Scientist (Research Project Advisor)

Or e-mail your CV/ resume to: robert.drust@cshs.org

Cedars-Sinai is an Equal Opportunity Employer that welcomes and encourages diversity in the workplace.