Columbia University in the City of New York, New York, United States
Two post-doctoral positions are available for immediate start in the laboratory of Dr Elizabeth Hillman. Our lab develops and then applies advanced in-vivo optical imaging and microscopy technologies to gain insight into the function of living tissue, organs and organisms. The following positions are available on two separate projects:
1) Neuroimaging: In-vivo microscopy and optical imaging of brain function Using rodent models, we are exploring the interrelation between blood flow and neuronal activity in the living intact brain. We combine high-speed camera imaging of the exposed cortex with multispectral in-vivo two-photon microscopy to animate the neurovascular coupling process via calcium sensitive dyes, transgenic models and hemoglobin absorption dynamics. We are seeking a post-doctoral fellow to conduct a range of experiments utilizing these tools to investigate neurovascular coupling and its underlying relation to cortical metabolism. Candidates will ideally have a neuroscience background and experience / interest in advanced imaging and microscopy. Matlab programming skills and data analysis expertise, as well as an interest in instrumentation development would be a significant advantage. fMRI experience would be valuable but is not required. This position is funded by an NIH R01 from the National Institute of Neurological Disorders and Stroke, and a grant from the Human Frontier Science Program (HFSP).
2) Small Animal Molecular Imaging We are developing a new small animal imaging technology for drug discovery and disease research known as 'Dynamic Contrast Enhancement' (DyCE) for Molecular Imaging. This technique investigates the dynamics of fluorescent dyes injected into the tail vein of a mouse during high-speed imaging. Recently featured on the cover of Nature Photonics, this method has the potential to have significant impact on current small animal imaging practices. We are seeking a post-doctoral fellow to conduct research related to DyCE to investigate and develop broader applications for the technique, and to collaborate with local researchers on implementing and evaluating the technique for specific biomedical targets. Candidates will have well-rounded experience in data acquisition and data analysis, as well as experience working with rodents. Interest and experience in biochemistry and molecular probe development would be a significant advantage, as would an established track record of performing well on collaborative and interdisciplinary research projects.
Candidates for both positions should be highly motivated and skilled at working in amicable, energetic, interdisciplinary teams. Positions will be based at Columbia's Morningside Campus in upper Manhattan, New York. Women and minority candidates are encouraged to apply, as are international scholars. Applicants should provide a copy of their CV and a brief statement of their research interests. For more information on our lab and project please visit: http://www.bme.columbia.edu/~hillman or contact Elizabeth Hillman directly at: eh2245@columbia.edu
